Long term (>1 wk) NSAID use. Use Caution/Monitor. Increased risk of upper GI bleeding. NSAIDs decrease prostaglandin synthesis. What is Celebrex? Use Caution/Monitor.oxaprozin decreases effects of eprosartan by pharmacodynamic antagonism. Minor/Significance Unknown. Monitor Closely (1)oxaprozin decreases effects of terazosin by pharmacodynamic antagonism. Minor/Significance Unknown. Caution is advised, both drugs have the potential to cause bleeding. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.valsartan, oxaprozin. Use Caution/Monitor.meloxicam and oxaprozin both increase serum potassium. For neuropathic pain (mainly diabetic peripheral neuropathy and postherpetic neuralgia), the anticonvulsants gabapentin, pregabalin, and oxcarbazepine produced small improvements in pain in the short term compared with placebo. Use Caution/Monitor. Comment: Increased risk of CNS stimulation and seizures with high doses of fluoroquinolones. Monitor Closely (1)eltrombopag increases levels of oxaprozin by decreasing metabolism. NSAIDs decrease prostaglandin synthesis. Long term (>1 wk) NSAID use. Minor (1)cephalexin will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. Increased risk of upper GI bleeding. irbesartan and oxaprozin both increase serum potassium. carvedilol and oxaprozin both increase serum potassium. Minor/Significance Unknown. Minor/Significance Unknown. HOW TO USE: Read the Medication Guide provided by your pharmacist before you start taking oxaprozin and each time you get a refill. Modify Therapy/Monitor Closely. oxaprozin, azilsartan. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment. Either increases toxicity of the other by Other (see comment). Modify Therapy/Monitor Closely. Monitor patients for symptoms of active or occult gastrointestinal bleeding. Use Caution/Monitor. Use Caution/Monitor. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.losartan, oxaprozin. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor.Minor (1)fenoprofen will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. aspirin/citric acid/sodium bicarbonate and oxaprozin both increase anticoagulation. Monitor Closely (1)triamterene and oxaprozin both increase serum potassium. tafluprost, oxaprozin. oxaprozin increases and metaproterenol decreases serum potassium. oxaprozin increases levels of tobramycin by decreasing renal clearance. aceclofenac will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. If your doctor decides that you need to use this medication between 20 and 30 weeks of pregnancy, you should use the lowest effective dose for the shortest possible time. oxaprozin increases and levalbuterol decreases serum potassium. Use Caution/Monitor. Use Caution/Monitor. Increased risk of bleeding events. Comment: Combination may increase risk of bleeding. Use Caution/Monitor. Minor/Significance Unknown. oxaprozin increases levels of pemetrexed by unspecified interaction mechanism. meclofenamate and oxaprozin both increase anticoagulation. Avoid or Use Alternate Drug. Monitor Closely (2)oxaprozin and choline magnesium trisalicylate both increase anticoagulation. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis. NSAIDs decrease prostaglandin synthesis. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor.nabumetone and oxaprozin both increase serum potassium. Either increases effects of the other by pharmacodynamic synergism. fosinopril, oxaprozin. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis. Use Caution/Monitor. Mechanism: Displacement of GABA from receptors in brain. oxaprozin increases and pirbuterol decreases serum potassium. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)oxaprozin, perindopril. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. oxaprozin, dexamethasone. Meloxicam versus Celebrex response time is something that makes a difference in which one is picked for treatment. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (2)acemetacin and oxaprozin both increase anticoagulation. oxaprozin and phytoestrogens both increase anticoagulation. acemetacin and oxaprozin both increase serum potassium. travoprost ophthalmic, oxaprozin. Risk of hypoglycemia.Minor (1)oxaprozin will increase the level or effect of chlorpropamide by acidic (anionic) drug competition for renal tubular clearance. Other (see comment). oxaprozin, perindopril. Use Caution/Monitor. Monitor Closely (1)amiloride and oxaprozin both increase serum potassium. Minor/Significance Unknown. SSRIs inhib. Modify Therapy/Monitor Closely. Manage and view all your plans together even plans in different states. Mean pain duration was 7.9 years, with a mean pain severity of 6 out of 10. Increased risk of upper GI bleeding. melatonin increases effects of oxaprozin by anticoagulation. Use Caution/Monitor. chlorthalidone will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. oxaprozin decreases effects of terazosin by pharmacodynamic antagonism. Monitor Closely (2)oxaprozin decreases effects of labetalol by pharmacodynamic antagonism. oxaprozin increases effects of glipizide by unknown mechanism. Monitor Closely (2)oxaprozin and sulfasalazine both increase anticoagulation. A collection of Implementing AHRQ Effective Health Care Reviews published in AFP is available at https://www.aafp.org/afp/ahrq. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Use Caution/Monitor. Risk of hypoglycemia. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Monitor Closely (2)oxaprozin decreases effects of nadolol by pharmacodynamic antagonism. Minor (1)oxaprozin increases levels of paromomycin by decreasing renal clearance. Either increases toxicity of the other by pharmacodynamic synergism. Other (see comment). The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Modify Therapy/Monitor Closely. Comment: May be associated with fluid and electrolyte imbalances. Use Caution/Monitor. Monitor Closely (1)oxaprozin and potassium acid phosphate both increase serum potassium. Use Caution/Monitor.oxaprozin decreases effects of timolol by pharmacodynamic antagonism. oxaprozin decreases effects of hydralazine by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. oxaprozin and noni juice both increase serum potassium. Use Caution/Monitor. In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs with drugs that affect RAAS may increase the risk of renal impairment (including acute renal failure) and cause loss of antihypertensive effect. Effect of interaction is not clear, use caution. Monitor Closely (1)oxaprozin, dexamethasone. Monitor Closely (1)oxaprozin increases effects of tolbutamide by unknown mechanism. Risk of hypoglycemia. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic). aspirin/citric acid/sodium bicarbonate will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. NSAIDs decrease prostaglandin synthesis. Monitor Closely (1)oxaprozin increases effects of chlorpropamide by unknown mechanism. Use Caution/Monitor. Minor/Significance Unknown. Created for people with ongoing healthcare needs but benefits everyone. Discuss the risks and benefits with your doctor or pharmacist.In certain conditions (such as arthritis), it may take up to 2 weeks when this drug is taken regularly before you notice the full benefits.Tell your doctor if your condition worsens. Oxaprozin is also used to treat rheumatoid arthritis in children who are at least 6 years old. Effect of interaction is not clear, use caution. oxaprozin will increase the level or effect of parecoxib by acidic (anionic) drug competition for renal tubular clearance. ketorolac and oxaprozin both increase serum potassium. (SOR: B, based on inconsistent or limited-quality patient-oriented evidence.) Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Either increases levels of the other by decreasing renal clearance. venlafaxine, oxaprozin. Long term (>1 wk) NSAID use. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. indomethacin will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. SSRIs inhib. Either increases toxicity of the other by pharmacodynamic synergism. Effect of interaction is not clear, use caution. Use Caution/Monitor. Coadministration may result in a significant decrease in renal function. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor.oxaprozin and sulfasalazine both increase serum potassium. Use Caution/Monitor. phenindione and oxaprozin both increase anticoagulation. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor.celecoxib and oxaprozin both increase serum potassium. Use Caution/Monitor. 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